Surface Plasmon Resonance (SPR) technique for evaluating direct binding of BRD2-2 to molecular inhibitors
Bromodomain-containing protein 2 domain 2 (aa 344-454)
O27.1.1, Really interesting new gene 3 protein
Reaction Biology Cat# RD-11-154
Malvern, PA, USA
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Binding of three BET bromodomain inhibitors to BRD2-2
The data was collected on a Biacore 8K using multi-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model or steady state affinity model to determine binding affinity (KD).