BRD2-2 SPR Assay Service

Surface Plasmon Resonance (SPR) technique for evaluating direct binding of BRD2-2 to molecular inhibitors

Target Overview


Bromodomain-containing protein 2 domain 2 (aa 344-454)

HGNC symbol



O27.1.1, Really interesting new gene 3 protein

Uniprot page

P25440 (

Protein Source:

Reaction Biology Cat# RD-11-154

Screening location

Malvern, PA, USA

Further information

More information can be found on our website SPR Assay Services for Drug Discovery

Binding of three BET bromodomain inhibitors to BRD2-2


The data was collected on a Biacore 8K using multi-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model or steady state affinity model to determine binding affinity (KD).