BRD3-1 SPR Assay Service

Surface Plasmon Resonance (SPR) technique for evaluating direct binding of BRD3-1 to molecular inhibitors

Target Overview

Target

Bromodomain-containing protein 3 domain 1 (aa 24-144)

HGNC symbol

BRD3

Synonyms

RING3-like protein

Scientific information

Q15059 (https://www.uniprot.org/uniprot/Q15059)

Protein source

Reaction Biology Cat# RD-11-163

Screening location

Malvern, PA, USA

Further information

More information can be found on our website SPR Assay Services for Drug Discovery

Binding of three BET bromodomain inhibitors to BRD3-1

BRD3-1 Binding

The data was collected on a Biacore 8K using multi-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model or steady state affinity model to determine binding affinity (KD).