Surface Plasmon Resonance (SPR) technique for evaluating direct binding of cereblon CULT domain to molecules
CULT Domain of Protein Cereblon (aa 316-442)
Malvern, PA, USA
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Binding kinetics of thalidomide and analogues pomalidomide and lenalidomide to the CULT domain of cereblon
The data was collected on a Biacore 8K using multi-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model and steady state affinity model to determine binding affinity (KD).