Cereblon CULT Domain SPR Assay Service

Surface Plasmon Resonance (SPR) technique for evaluating direct binding of cereblon CULT domain to molecules

Target Overview


CULT Domain of Protein Cereblon (aa 316-442)

HGNC symbol




Uniprot page

Q96SW2 (https://www.uniprot.org/uniprot/Q96SW2)

Screening location

Malvern, PA, USA

Further information

More information can be found on our website SPR Assay Services for Drug Discovery

Binding kinetics of thalidomide and analogues pomalidomide and lenalidomide to the CULT domain of cereblon

Cereblon short binding data

The data was collected on a Biacore 8K using multi-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model and steady state affinity model to determine binding affinity (KD).