Full Length cGAS SPR Assay Service

Nucleotidyltransferase cGAS (full length) assay with surface plasmon resonance (SPR) format

Target Overview

Human full-length cGAS

HGNC symbol



Cyclic GMP-AMP synthase, cGAMP synthase

Assay Properties
Scientific information

Binding kinetics and steady state affinity of PF-06928215 to full-length cGAS

Full Length cGAS SPR


The data was collected on a Biacore 8K using multi-cycle kinetics. Full-length cGAS was immobilized to the sensor chip and the binding of PF-06928215 was measured. The binding data was analyzed using both a 1:1 kinetic binding model and a steady state affinity model. The binding kinetics and affinity are consistent with the data for PF-06928215 binding to the shorter cGAS construct (AA 157-522).