Full Length cGAS SPR Assay Service

Nucleotidyltransferase cGAS (full length) assay with surface plasmon resonance (SPR) technique

Target Overview


Human full-length cGAS

HGNC symbol



Cyclic GMP-AMP synthase, cGAMP synthase

Scientific information

Screening location

Malvern, PA, USA

Further information

More information can be found on our website SPR Assay Services for Drug Discovery

Binding kinetics and steady state affinity of reference compound (PF-06928215) to full-length cGAS

Full Length cGAS SPR


The data was collected on a Biacore 8K using multi-cycle kinetics. Full-length cGAS was immobilized to the sensor chip and the binding of PF-06928215 was measured. The binding data was analyzed using both a 1:1 kinetic binding model and a steady state affinity model. The binding kinetics and affinity are consistent with the data for PF-06928215 binding to the shorter cGAS construct (AA 157-522).