Activity-based PARG (Poly(ADP-ribose) glycohydrolase) assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PARG
Enzyme
Human PARG
Synonym
Poly(ADP-ribose) glycohydrolase
Scientific Information
Q86W56 (http://www.uniprot.org/uniprot/Q86W56)
Assay Properties
Substrate
TFMU-ADPr
Reaction
TFMU-ADPr = TFMU + ADPr
TFMU fluorescence, kinetic measurement
Readout
Enzymatic activity
Reference Compound IC50s
Compounds | IC50 (nM) |
---|---|
PDD 00017273 | 1.6 |
ADP-HPD | 78.4 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Poly (ADP-ribose) Polymerase (PARP) Assay Services
Reference compound inhibition for PARG
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