PARG Assay Service

Activity-based PARG (Poly(ADP-ribose) glycohydrolase) assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.

Target Overview
CAT#

PARG

Enzyme

Human PARG

Synonym

Poly(ADP-ribose) glycohydrolase

Scientific Information

Q86W56 (http://www.uniprot.org/uniprot/Q86W56)

Assay Properties
Substrate

TFMU-ADPr

Reaction

TFMU-ADPr = TFMU + ADPr
TFMU fluorescence, kinetic measurement

Readout

Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
PDD 00017273 1.6
ADP-HPD 78.4
Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Poly (ADP-ribose) Polymerase (PARP) Assay Services

Reference compound inhibition for PARG

Reference compound inhibition for PARG