Surface Plasmon Resonance (SPR) technique for evaluating direct binding of PRMT1 to molecular inhibitors
Protein arginine N-methyltransferase 1
Produced at Reaction Biology. Catalog # HMT-11-119
Malvern, PA, USA
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Binding of reference compound (SAH) to PRMT1
The data was collected on a Biacore 8K using multi-cycle kinetics. The data was analyzed using a steady state affinity model determine binding affinity (KD).
Binding of GSK3368715 to PRMT1 in the presence of SAM
The data was collected on a Biacore 8K using single-cycle kinetics. The data was analyzed using a 1:1 kinetic binding model to determine binding affinity (KD).