SHP2 SPR Assay Service

Protein tyrosine phosphatase SHP2 assay with surface plasmon resonance (SPR) format

Target Overview
Target

SHP2

HGNC symbol

PTPN11

Synonyms

Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D (PTP-1D), Protein-tyrosine phosphatase 2C (PTP-2C), SH-PTP2, SH-PTP3

Assay Properties
Scientific information

Q06124 (https://www.uniprot.org/uniprot/Q06124)

Binding of allosteric inhibitor SHP099 to SHP2

SHP099 Binding SHP2

 

The data was collected on a Biacore 8K using single-cycle kinetics. SHP2 was immobilized to the sensor chip and the binding of allosteric inhibitor SHP099 was measured. The binding data was analyzed using a 1:1 kinetic binding model.