Protein tyrosine phosphatase SHP2 assay with surface plasmon resonance (SPR) technique
Target Overview
Target
SHP2
HGNC symbol
PTPN11
Synonyms
Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D (PTP-1D), Protein-tyrosine phosphatase 2C (PTP-2C), SH-PTP2, SH-PTP3
Scientific information
Q06124 (https://www.uniprot.org/uniprot/Q06124)
Screening location
Malvern, PA, USA
Further information
More information can be found on our website SPR Assay Services for Drug Discovery
Binding of allosteric inhibitor SHP099 to SHP2
![SHP099 Binding SHP2](/wp-content/uploads/2023/11/SHP099%20Binding%20SHP2.png?itok=rnmI0R8j)
The data was collected on a Biacore 8K using single-cycle kinetics. SHP2 was immobilized to the sensor chip and the binding of allosteric inhibitor SHP099 was measured. The binding data was analyzed using a 1:1 kinetic binding model.
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