To test the direct binding to the SMARCA2b bromodomain using surface plasmon resonance (SPR) technique
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (bromodomain)
BAF190B, BRM, SNF2L2
Malvern, PA, USA
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Binding kinetics of reference compound (PFI-3) to the bromodomain of SMARCA2b.
The data was collected on a Biacore 8K using multi-cycle kinetics. A reduced DMSO condition was used. The data was analyzed using both a 1:1 kinetic binding model and a steady state affinity model to determine binding affinity (KD).