Receptor tyrosine kinase EGFR assay using surface plasmon resonance (SPR) technique
Wildtype EGFR (aa 671-998)
Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Malvern, PA, USA
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Binding kinetics of lapatinib to wildtype EGFR
The data was collected on a Biacore 8K using single-cycle kinetics. Wildtype EGFR (AA 671-998) was captured the sensor chip and the binding of lapatinib was measured. The binding data was analyzed using a 1:1 kinetic binding model.