SOS1 fragment aa 564-1049
Son of sevenless homolog 1, SOS Ras/Rac guanine nucleotide exchange factor 1
Binding kinetics of BAY-293 to SOS1
The data was collected on a Biacore 8K using single-cycle kinetics. SOS1 was immobilized to the sensor chip then BAY-293 at increasing concentrations flowed over the chip, and the binding responses were measured. A 1:1 kinetic binding model was used to fit the data and obtain the on/off-rates and KD.