SOS1 Binding Kinetic Assay Service via SPR

K-Ras related Assays: Binding kinetics of agents to SOS1 are measured via surface plasmon resonance (SPR) technique

Target Overview

SOS1 fragment aa 564-1049


Son of sevenless homolog 1, SOS Ras/Rac guanine nucleotide exchange factor 1

Assay Properties
Scientific information

Binding kinetics of BAY-293 to SOS1

sos1 surface plasmon resonance


The data was collected on a Biacore 8K using single-cycle kinetics. SOS1 was immobilized to the sensor chip then BAY-293 at increasing concentrations flowed over the chip, and the binding responses were measured. A 1:1 kinetic binding model was used to fit the data and obtain the on/off-rates and KD.