SOS1 Binding Kinetic Assay Service via SPR

K-Ras related Assays: Binding kinetics of agents to SOS1 are measured via surface plasmon resonance (SPR) technique

Target Overview


SOS1 fragment aa 564-1049


Son of sevenless homolog 1, SOS Ras/Rac guanine nucleotide exchange factor 1

Scientific information

Screening location

Malvern, PA, USA

Further information

More information can be found on our website SPR Assay Services for Drug Discovery

Binding kinetics of reference compound (BAY-293) to SOS1


The data was collected on a Biacore 8K using single-cycle kinetics. SOS1 was immobilized to the sensor chip then BAY-293 at increasing concentrations flowed over the chip, and the binding responses were measured. A 1:1 kinetic binding model was used to fit the data and obtain the on/off-rates and KD.