Cardiac Safety Assessment Assay Services

The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.

Ion channels are a diverse class of membrane proteins that play important roles in physiology. Deficits or the increase of ion channel activity caused by the activity of pharmacological agents are linked to several disease conditions. The inhibition of cardiac ion channels is linked to the generation of life-threatening arrhythmias. Therefore it is important to screen compounds against these channels to assess potential cardiac liability.

Screening options include:

• Cell-based patch clamp
• In vitro hERG binding assay
• Tissue-based microelectrode intracellular action potential recording
• Organ-based Langendorff isolated heart ECG recording