3D ProLiFiler™ Spheroid Cancer Cell Panel Screening Service
The three-dimensional (3D) ProLiFilerTM spheroid panel screening service enables scientists to analyze the therapeutic potency and tumor-penetrating efficacy of new anti-cancer compounds on 3D spheroids grown from a panel of 40 distinctive cell lines derived from 13 tumor entities. This service provides an efficient way to check for compound efficacy against 40 common tumor cell lines.
3D tumor spheroids, also known as cancer spheroids, are composed of tumor cells in various proliferative and metabolic states and have demonstrated to mimic complex physiological tumor processes like tumorigenesis, microenvironment, heterogeneity, and tumor-immune interaction. Testing cancer drug candidates on a panel of 3D spheroids grown from distinct tumor cell lines with important clinical mutations yields high-quality data from a physiologically relevant in vitro assay format, making it a valuable tool for lead candidate selection for further in vivo studies.
3D ProLiFilerTM spheroid cancer cell panel screening key advantages:
- Evaluate drug responses in using a 3D model across 40 cell lines to better understand compound effectiveness and prioritize the most suitable and potent compounds before moving to in vivo studies.
- A more physiologically relevant model that mimics in vivo tumor biology, signaling cascades, and tumor progression with reproduced gradients of oxygenation, nutrition, and pH.
- 3D spheroids reflect the tumor microenvironment by modeling 3D cell-cell attachment, interaction, and cell-ECM interactions.