Assays for COVID-19 Drug Discovery

To support the drug discovery community in the challenge to identify efficacious COVID-19 drugs, we have developed specific assays to block SARS-CoV-2 virus entry and replication.

The SARS-CoV-2 S protein and ACE2 binding assay is used to measure the direct binding of potential therapeutics to the S protein receptor-binding domain or ACE2 to determine the kinetics of the interaction or to measure whether the test molecule(s) disrupt the S protein /ACE2 interaction.

We offer compound screening assays targeting proteases that are essential for SARS-CoV-2 virus entry and replication.