Syngeneic Mouse Models

Syngeneic mouse models are used for efficacy testing of immuno-oncologic drugs and the investigation of the effects of conventional anti-cancer drugs on the immune system. In a syngeneic model, the tumor tissue was obtained from a mouse of the same genetic background as the immuno-competent recipient mouse. With the tumor microenvironment and transplanted cells belonging to the same strain, syngeneic models are powerful immuno-oncology models for investigating responses to anti-cancer therapies.

Our panel of cell line-derived syngeneic tumor models (CDX) comprises subcutaneous, subQperior, orthotopic, and metastasis models. Our innovative subQperiorTM tumor models are based on cell implantation into the mammary fat pad of mice and feature reduced tumor ulceration and yield more homogeneous tumor growth and ultimately outstanding statistical evaluation of drug efficacy testing.

In addition to standard syngeneic tumor models, Reaction Biology also offers proprietary tissue-based immuno-oncology models, named Mouse-derived Isograft Models (MDI).

  • Science-driven study setup with a focus on reproducible and meaningful results
  • Custom-tailored reports written by Ph.D. level medical writers will be provided for every in vivo study
  • All procedures entail a meticulous documentation process according to GV-Solas requirements and are in-line with the ISO 9001 certification
  • Regular syngeneic panel screening of 6 syngeneic tumor models for economic efficacy evaluation of new immuno-oncology drug candidates
  • Comprehensive flow cytometry analysis capacity with 17 marker staining panel

Reaction Biology has a global network of business development managers to understand your specific research needs and help determine the right mouse models for your immunotherapy research thrust. Throughout the study, you will work with just one team of scientists to facilitate consistent communication. Inquire for our models today.

Cell line-derived Syngeneic Mouse Models

Cell Line Tissue Orgin Disease Available Models at Hershey, PA, USA Available Models at Freiburg, Germany
4T1 Breast Malignant neoplasms of the mouse mammary gland subcutaneous; orthotopic
AB12 Lung Mesothelioma
B16-F0 Skin Melanoma subcutaneous; orthotopic
B16-F10 Skin Melanoma subcutaneous; orthotopic
C1498 Blood Acute myeloid leukemia, lymphoblast subcutaneous
Clone M3/Cloudman S91 Skin Melanoma
CT26wt Colon Colon adenocarcinoma subcutaneous
E.G7-OVA Blood T lymphoblast subcutaneous
EMT6 Breast Breast carcinoma subcutaneous; orthotopic
GL261 Brain Glioblastoma subcutaneous; orthotopic
HC11-NeuT Breast Breast epithelial cell line transformed with NeuT (rat ErbB2 homolog) subcutaneous
Hepa1-6 Liver Hepatocellular carcinoma subcutaneous
LL/2 (LLC1) Lung Lewis lung carcinoma subcutaneous; orthotopic
MB-49 Bladder Urinary bladder carcinoma subcutaneous; orthotopic
MC-38 Colon Colon adenocarcinoma subcutaneous
MC38-CEA# Colon Colon adenocarcinoma
Pan02 Pancreas Pancreatic ductal adenocarcinoma subcutaneous; orthotopic subQperior; orthotopic
RENCA Kidney Kidney carcinoma subcutaneous

* subQperior substitute subcutaneous tumor models
# Carcinoembryonic antigen suited for the investigation of tumor-specific T cell response

Looking for human tumor models? Please visit Xenograft Models for more information.

Options for Tumor Placement