Genetically engineered tumor models are well suited for the investigation of a single driver of tumor growth such as an overexpressed or constitutively expressed kinase.
Reaction Biology offers two models based on fibroblast cells which were engineered to express an exogenous receptor kinase under the control of an inducible promoter. These models make excellent tools for the investigation of inhibitors in the in vivo setting.
Target a human kinase in mice with an intact immune system
Implantation of engineered cells for comparable tumor growth
Assess compound efficacy and evaluate mechanisms of drug resistance