Targeted Protein Degradation Assay Services
Targeted protein degraders comprise a class of molecules that induce protein degradation of a specific disease-causing protein by the cell's ubiquitin-proteasome pathway. In the past few years, various molecule classes have evolved including PROTACs (Proteolysis-targeting chimeras), molecular glue, selective receptor degraders, and cerebron-binding molecules, to name a few.
All protein degraders have in common a drug discovery approach that is different from the classic inhibition of the function of a target. The discovery of new molecules facilitating targeted protein degradation requires a set of assays to investigate the binding of a drug to target, the structure of the drug-target complex as well as the degradation of the target from the cell.
Protein Degradation via PROTACs
A PROTAC molecule consists of three parts – the target binding head and a E3 ligase interacting part which are connected via a linker. The PROTAC draws the target into a ternary complex with the ubiquitination complex tagging the target for degradation via proteasomes.
We are currently talking to biotech and pharma companies to perform fee-for-service, shared-cost collaboration or FTE-based work for the development of new protein degradation molecules. Please reach out to our Business Development Team to discuss options for supporting your drug discovery program.