Maximum Tolerable Dose Study Services
The identification of the Maximum-Tolerable Dose (MTD) is one of the first steps when taking a drug candidate from in vitro to in vivo phase of drug discovery. The MTD is used to define the upper limit of dosing for efficacy testing, ensuring that drug exposure is high enough to evaluate activity but not so high that results are confounded by systemic toxicity.
The frequency and the route of administration play a role in the MTD as well as the mouse strain and the gender.
Maximum tolerable dose studies can be performed in naive or tumor-bearing mice, since tumor exposure can have an impact on how a mouse tolerates a drug.
