by Andrew Khouri | Aug 13, 2024 | Blog
The ATP binding site of kinases represents both a golden opportunity and a formidable challenge for drug discovery teams. This well-defined pocket serves as the docking site for potent small-molecule inhibitors, making it an attractive target for drug development....
by Andrew Khouri | Aug 6, 2024 | Uncategorized
The concept of Bioluminescence Resonance Energy Transfer draws its inspiration directly from nature. In the jellyfish Aequorea victoria, bioluminescence is orchestrated through the interaction of aequorin and green fluorescent protein (GFP). Aequorin, a...
by Andrew Khouri | Jul 18, 2024 | Blog
Macrophages: Double-Edged Swords in Cancer Macrophages are phagocytic cells that eliminate pathogens and modulate adaptive immunity through cytokine secretion. However, within the TME, they exhibit phenotypic plasticity, adopting either an anti-tumor M1 or pro-tumor...
by Andrew Khouri | Jul 2, 2024 | Blog
The journey of kinase drug discovery is a fascinating tale, sparked by Nobel Laureate Edmund Fischer’s discovery of protein phosphorylation. With the identification of over 500 protein kinases in the human genome, their crucial role in cellular regulation became...
by Andrew Khouri | Jun 20, 2024 | Uncategorized
The quest to develop new immunotherapeutic medicines relies heavily on effective preclinical research. Central to this research are in vivo animal tumor models with fully functional immune systems. Among these, syngeneic tumor models have emerged as powerful tools,...
