Reaction Biology offers a broad panel of recombinant proteins for epigenetic drug discovery. Quality control steps are performed with enzymes to ensure enzymatic activity. All of our recombinant proteins are purified via one or two chromatographic separation cycles.
Our recombinant proteins can be purchased as aliquots off-the-shelf or in bulk quantities. Custom-tailored recombinant protein expression can be performed according to your specific requirements of active kinases and other potential drug targets.
Methyltransferases modulate genetic function in humans and are the subject of intense research in the pharmaceutical industry to validate them as targets for a new generation of cancer drugs. Reaction Biology offers the largest collection of active methyltransferase enzymes for purchase.
Methyltransferase substrates are useful for the assay of various histone methyltransferases either by radiolabeling with [3H]-S-adenosylmethionine or by methods employing site/modification-specific antibodies. Reaction Biology offers several methyltransferase substrates for purchase.
Epigenetic reader domain proteins recognize and are recruited to specific marks on histones or nucleotides. Reaction Biology offers the largest collection of reader domain proteins (100+) for purchase.
HDAC proteins are therapeutic targets for cancer, neurodegenerative diseases, and several other disorders. Reaction Biology offers several HDAC proteins for purchase.
Reaction Biology currently offers LSD1 and CoRest as a part of their protein demethylation collection for purchase.
Reaction Biology's DNA Demethylation and Repair offering currently includes the APE1 protein.
IDH (isocitrate dehydrogenase) proteins are involved in hypermethylating DNA and histones, which can result in altered gene expression that can activate oncogenes and inactivate tumor-suppressor genes. Reaction Biology offers IDH proteins for purchase.
PARP proteins (Poly ADP-ribose polymerase proteins) are involved in numerous cellular processes involving DNA repair and programmed cell death. Reaction Biology offers several PARP proteins for purchase
NQO (NAD(P)H dehydrogenase quinone) proteins are responsible for preventing the one-electron reduction of quinones that results in the creation of radical species. Reaction Biology offers several NQO proteins for purchase.
NUDIX & Nucleotide Pool Sanitation
NUDIX & nucleotide pool sanitation proteins prevent misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription through their involvement in the sanitization of nucleotide pools. Reaction Biology offers NUDIX & nucleotide pool sanitation proteins for purchase.
Reaction Biology offers a suite of pro- and anti-apoptotic proteins for purchase.
Reaction Biology offers a variety of inhibitors of epigenetic events, such as DNA methylation and covalent modification of histones for purchase.
Reaction Biology offers additional proteins such as Diaphorase, SHP2, and O-GlcNAc transferase for purchase.
Purchase our BromoMELTTM Assay Kit for DIY bromodomain selectivity screening.