CYP450 Inhibition Assay Services
Cytochromes (CYPs) are hemeproteins that play key roles in the metabolism of drugs. Understanding a compound’s inhibitory activity against key CYP proteins is essential for predicting drug-drug interactions. Reaction Biology provides compound profiling against the 12 most important CYP isoforms to provide early guidance on a compound’s toxicity.
Our CYP450 Inhibition Assays are performed with the Vivid CYP450 Assay Technology (ThermoFisher) to detect the activity of CYP enzymes in a simple “mix-and-read” fluorescent assay which is suitable for high-throughput analysis.
- Low and large scale, as well as high-throughput CYP profiling options, are available
- Custom-tailored CYP450 assay development possible
- The inhibition of CYP activity by drug candidates is measured via fluorescence readout
