In Vivo Pharmacology


Reaction Biology offers three methods for immunophenotyping which is crucial for the investigation of immunotherapeutics. The following options are available at Reaction Biology:

  • Flow cytometry is available to investigate the frequency of immune cells in tumor tissue and evaluate the immune-modulating effects of drugs.
  • Multiplexing immune markers including cytokines and chemokines can be performed by the highly sensitive mesoscale discovery (MSD) platform.
  • At the animal study endpoint, tumor tissue can be isolated and snap-frozen or embedded for histology or immunohistochemical investigation. A TMA can be assembled for streamlined processing and staining of several dozen tumor samples on one slide.
  • Tissue cores of tumors of our syngeneic tumor models are available in a tissue microarray (TMA). Data for the frequency of CD3, CD4, CD8, and CD11b positive cells can be seen in our TMA Gallery.
Immunohistochemistry & TMA Immune cell localization via IHC Multiplex MSD Immune signatures via cytokine/chemokine quantification Flow Cytometry Quantification of Immune cell frequencies

Reaction Biology offers flow cytometry analysis for investigating the frequency of tumor-infiltrating immune cells, multiplex assays for testing the cytokine environment, and immunohistology to visualize the location of immune cells in tumor tissue.

Talk to our Business Development Manager team today to discuss your immunophenotyping needs.