Overview of ADME and Safety-related Services

The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.

The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.

Reaction Biology provides compound profiling against the 6 most important CYP isoforms to provide early guidance on a compound's toxicity.

Pharmacokinetics (PK) is a fundamental aspect of drug discovery for characterization of drug candidates in hit-to-lead and lead optimization programs in regards of adsorption, distribution, metabolism and excretion after administration to mice.

The identification of the Maximum-Tolerated Dose (MTD) is one of the first steps when taking a drug candidate from in vitro to in vivo phase of drug discovery. The MTD is the dose at which certain toxicity specified in advance occurs only in a predetermined tolerable proportion of the animals.