Overview of ADME and Safety-related Services

Pharmacokinetics (PK) is a fundamental aspect of drug discovery for characterization of drug candidates in hit-to-lead and lead optimization programs in regards of adsorption, distribution, metabolism and excretion after administration to mice.

The identification of the Maximum-Tolerated Dose (MTD) is one of the first steps when taking a drug candidate from in vitro to in vivo phase of drug discovery. The MTD is the dose at which certain toxicity specified in advance occurs only in a predetermined tolerable proportion of the animals.

The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.