The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.
The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.
Pharmacokinetics (PK) is a fundamental aspect of drug discovery for characterization of drug candidates in hit-to-lead and lead optimization programs in regards of adsorption, distribution, metabolism and excretion after administration to mice.
The identification of the Maximum-Tolerated Dose (MTD) is one of the first steps when taking a drug candidate from in vitro to in vivo phase of drug discovery. The MTD is the dose at which certain toxicity specified in advance occurs only in a predetermined tolerable proportion of the animals.
