Kinase Drug Discovery Services

Reaction Biology offers the largest portfolio of kinase assays in the industry. We are dedicated to providing end-to-end service for kinase drug discovery covering all steps of the preclinical drug discovery process.

Shortcut to our complete kinase target list here.

Kinase Assay Services

Biochemical kinase assays are used to measure the effects of compounds on kinase activity for IC50 value determination or high-throughput screening.

Kinase Panel Screening

The improvement of the selectivity of a compound by screening a large part of the kinome is of pivotal importance in the discovery process of novel kinase inhibitors.

Cellular Kinase Assays

EGFR Drug Discovery

Reaction Biology supports EGFR Drug Discovery with a suite of biochemical, biophysical, cell-based, and in vivo services for the creation of the next generation of EGFR inhibitors.

Kinase SubstrateFinder

The Kinase SubstrateFinder is a biochemical kinase assay that can be used for the identification of suitable substrates for a specific kinase of interest for example for assay development or pathway identification.

KinaseFinder

The KinaseFinder is a biochemical assay intended to identify kinases, which accept a given substrate for phosphorylation.

Customized Kinase Drug Discovery

Custom-tailored kinase screening and mechanism of action studies can be performed with either our portfolio of assays or with a kinase or substrate provided by the customer.

In Vivo Kinase Activity Models

Genetically engineered tumor models are well suited for the investigation of a single driver of tumor growth such as an overexpressed or constitutively expressed kinase.