Mouse-Derived Isograft Tumor Models (MDI)
Our proprietary mouse-derived isograft tumor models (MDI) allow drug efficacy testing in a setting that recapitulates the original tumor very closely.
While cell line-derived syngeneic tumor models are based on the implantation of cultured cell lines, our proprietary mouse-derived isograft (MDI) tumor models are propagated in mice only. Hence, the major advantage of these novel spontaneous-derived or carcinogen-induced MDI tumor models is the preservation of primary tumor phenotype and intratumoral immune cell populations.
- Derived from spontaneous or carcinogen-induced mouse tumors
- Allow for the identification of biomarkers
- Efficacy testing with high predictive value for patient-derived xenograft models
‘Murine PDX‘
Cell line-derived syngeneic tumor models are limited in their availability and phenotypes and barely resemble their original primary tumors due to many passages in cell culture.
Our novel MDI models increase the palette of the available syngeneic models and allow drug testing in tumors resembling primary tumors for higher translatability.
MDI Models
| Model | Origin | Creation | Efficacy* | RNAseq | Info sheet |
|---|---|---|---|---|---|
| JA-2042 | sarcoma | carcinogen | yes | yes | Data sheet |
| JA-0009 | adenocarc. | spontaneous | yes | yes | Data sheet |
| JA-0017 | adenocarc. | spontaneous | ongoing | ongoing | Data sheet |
| JA-2011 | sarcoma | carcinogen | yes | yes | Data sheet |
| JA-2019 | sarcoma | carcinogen | yes | ongoing | Data sheet |
| JA-2041 | sarcoma | carcinogen | yes | ongoing | Data sheet |
Characteristics of MDI Models
| Model | anti-PD1 | anti-CTLA-4 | Combination | therapeutic window | relevant immune cells |
|---|---|---|---|---|---|
| JA-0009 | low | low | low | 2 weeks | M2 macrophages |
| JA-0017 | nd | nd | nd | >6 weeks | nd |
| JA-2011 | low | low | nd | 2 weeks | neutrophils |
| JA-2019 | high | high | nd | 2 weeks | MDSCs/Tcells |
| JA-2041 | moderate | moderate | nd | 3 weeks | MDSCs/Tcells |
| JA-2042 | moderate | moderate | high | 2 weeks | Treg cells |
Related Resources
