Mouse-Derived Isograft Tumor Models (MDI)

Our proprietary mouse-derived isograft tumor models (MDI) allow drug efficacy testing in a setting that recapitulates the original tumor very closely. Tumor tissue was isolated from mice with cancer and the tissue was engrafted for propagation into other mice - also called tumor homograft model.

While cell line-derived syngeneic tumor models are based on the implantation of cultured cell lines, our proprietary mouse-derived isograft (MDI) models are propagated in mice only. Hence, the major advantage of these novel spontaneous-derived or carcinogen-induced MDI tumor models is the preservation of primary tumor phenotype and intratumoral immune cell populations.

• Derived from spontaneous tumors or carcinogen-induced tumors
• Allow for the identification of biomarkers
• Efficacy testing with high predictive value for patient-derived xenograft models