Complete List of Reaction Biology’s Kinase Targets

Reaction Biology is the industry leader in contract research for kinase drug discovery. Our offering comprises

recombinant kinase proteins and substrates
assays for biochemical screening in either free choice format or kinase panel screening at two locations, our research site in Malvern, US and Freiburg, Germany
biophysical compound screening with SPR, TSA, ITC, or MST
three cell-based kinase assay formats including the NanoBRET Target Engagement Assay, the Cellular Phosphorylation Assay, and the BaF3 Cell Proliferation Assay

Check out our complete list of kinase assays below.

HGNC reference	Synonyms	Biochemical Assay US	Biochemical Assay Germany	Cellular Phosphorylation Assay	NanoBRET Assay	BaF3 Cell Proliferation Assay
AAK1	AP2 associated kinase1	No	No	No	Yes	No
ABL1	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (E255K)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (E255V)	ABL, JTK7, p150, c-ABL, v-abl	Yes	No	No	No	No
ABL1 (F317I)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (F317L)	ABL, JTK7, p150, c-ABL, v-abl	Yes	No	No	Yes	No
ABL1 (G250E)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	No	No
ABL1 (H396P)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (M351T)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (Q252H)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (T315I)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (V299L)	ABL, JTK7, p150, c-ABL, v-abl	Yes	No	No	No	No
ABL1 (Y245F)	ABL, JTK7, p150, c-ABL, v-abl	Yes	No	No	No	No
ABL1 (Y245F/Y412F)	ABL, JTK7, p150, c-ABL, v-abl	Yes	No	No	No	No
ABL1 (Y253F)	ABL, JTK7, p150, c-ABL, v-abl	Yes	Yes	No	Yes	No
ABL1 (Y253H)	ABL, JTK7, p150, c-ABL, v-abl	Yes	No	No	No	No
ABL2	ABLL, ARG	Yes	Yes	No	Yes	No
ACVR1	ACTRI, ACVRLK2, ALK2, SKR1	Yes	Yes	No	Yes	No
ACVR1 (G328V)	ACTRI, ACVRLK2, ALK2, SKR2	No	No	No	Yes	No
ACVR1 (G356D)	ACTRI, ACVRLK2, ALK2, SKR3	No	No	No	Yes	No
ACVR1 (Q207D)	ACTRI, ACVRLK2, ALK2, SKR1	Yes	No	No	Yes	No
ACVR1 (R206H)	ACTRI, ACVRLK2, ALK2, SKR1	Yes	No	No	Yes	No
ACVR1B	ACTRIB, ACVRLK4, ALK4, SKR2	Yes	Yes	No	Yes	No
ACVR2A	P61160	No	Yes	No	No	No
ACVR2B	Q13705	No	Yes	No	No	No
ACVRL1	ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3	Yes	Yes	No	Yes	No
ADK	AK	No	No	No	Yes	No
AKT1	PKB, RAC, PRKBA, RAc-ALPHA	Yes	Yes	Yes	Yes	No
AKT1 (E17K)	PKB, RAC, PRKBA, RAc-ALPHA	Yes	No	No	Yes	No
AKT1 (aa106-480)	P31749	No	Yes	No	No	No
AKT2	PRKBB, PKBBETA, RAc-BETA	Yes	Yes	No	Yes	No
AKT2 (E17K)	PRKBB, PKBBETA, RAc-BETA	Yes	No	No	Yes	No
AKT2 (aa107-481)	P31751	No	Yes	No	No	No
AKT3	PKBG, PKB gamma, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2	Yes	Yes	No	No	No
AKT3 (E17K)	PKBG, PKB gamma, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2	Yes	No	No	Yes	No
AKT3 (G171R)	PKBG, PKB gamma, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2	Yes	No	No	Yes	No
AKT3 (aa106-479)	Q9Y243	No	Yes	No	No	No
ALK	CD246, NBLST3	Yes	Yes	Yes	No	No
ALK (C1156Y)	CD246, NBLST3	Yes	Yes	No	No	No
ALK (F1174L)	CD246, NBLST3	Yes	Yes	No	No	No
ALK (F1174L)-EML4	CD246, NBLST3, EML4-ALK (F1174L)	Yes	Yes	No	No	No
ALK (F1174L)-NPM1	CD246, NBLST3, NPM1-ALK (F1174L)	Yes	Yes	No	No	No
ALK (F1174S)	CD246, NBLST3	Yes	Yes	No	No	No
ALK (G1202R)	CD246, NBLST3	Yes	Yes	No	No	No
ALK (G1269A)	CD246, NBLST3	Yes	No	No	No	No
ALK (G1269S)	CD246, NBLST3	Yes	No	No	No	No
ALK (L1152R)	CD246, NBLST3	Yes	No	No	No	No
ALK (L1196M)	CD246, NBLST3	Yes	Yes	No	No	No
ALK (L1196M/G1202R)	CD246	Yes	No	No	No	No
ALK (R1275Q)	CD246, NBLST3	Yes	Yes	No	No	No
ALK (S1206R)	CD246, NBLST3	Yes	No	No	No	No
ALK (T1151-L1152insT)	CD246, NBLST3	Yes	No	No	No	No
ALK (T1151M)	CD246, NBLST3	Yes	No	No	No	No
ALK-EML4	CD246, EMAP-4	Yes	Yes	No	No	No
ALK-KIF5B	CD246, NBLST3, KIF5B-ALK	Yes	No	No	No	No
ALK-KLC1	CD246, NBLST3, KCL1-ALK	Yes	No	No	No	No
ALK-NPM1	CD246, NBLST3, NPM1-ALK	Yes	Yes	No	No	No
ALK-STRN	CD246, Striatin	Yes	No	No	No	No
ALK-TFG	CD246, NBLST3, TFG-ALK	Yes	No	No	No	No
ALK-TPM1	CD246, NBLST3, TPM1-ALK	Yes	No	No	No	No
ALK-TPM3	CD246, NBLST3, TPM3-ALK	Yes	No	No	No	No
ARAF (Y301D/Y302D)	A-RA, ARAF1, PKS2, RAFA1, ARAF YDYD	Yes	Yes	No	No	No
ATM	TEL1, TELO1	Yes	No	Yes	No	No
AURKA	AurA, AIK, ARK1, AURA, BTAK, STK15, AuroraA, Aurora A	Yes	Yes	No	Yes	No
AURKB	AurB, AIK2, AIM1, ARK2, AurB, IPL1, STK5, AuroraB, Aurora B	Yes	Yes	Yes	Yes	No
AURKB (G160L)	AurB, AIK2, AIM1, ARK2, AurB, IPL1, STK5, AuroraB, Aurora B	Yes	No	No	No	No
AURKC	AurC, AIE2, AIK3, STK13, Aurora C, AuroraC	Yes	Yes	No	Yes	No
AXL	EC, UFO	Yes	Yes	Yes	Yes	No
AXL (R199C)	EC, UFO	Yes	No	No	No	No
BCR-ABL1	K562	No	No	Yes	No	No
BLK	BLK	Yes	Yes	No	Yes	No
BMP2K	BMP2 inducible kinase, BIKe	No	No	No	Yes	No
BMPR1A	SKR5, CD292, ALK3, ACVRLK3	Yes	Yes	No	Yes	No
BMPR1B	ALK6, CDw293	Yes	Yes	No	No	No
BMPR2	BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK	Yes	No	No	No	No
BMX	ETK, PSCTK2, PSCTK3	Yes	Yes	No	Yes	No
BRAF	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	Yes	No	No	No
BRAF (G464V)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (G469A)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (K601E)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (L597V)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (R506_K507insVLR)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (T599_V600insT)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (V600A)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (V600D)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (V600E)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	Yes	Yes	Yes	No
BRAF (V600K)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF (d485-489/P490Y)	B-Raf, B-raf-1, BRAF1, RAFB1	Yes	No	No	No	No
BRAF-FAM131B	B-Raf, B-raf-1, BRAF1, RAFB1, FAM131B-BRAF	Yes	No	No	No	No
BRAF-KIAA1549 (Kex15Bex9)	B-Raf, B-raf-1, BRAF1, RAFB1, KIAA1549-BRAF	Yes	No	No	No	No
BRAF-KIAA1549 (Kex16Bex9)	B-Raf, B-raf-1, BRAF1, RAFB1, KIAA1549-BRAF	Yes	No	No	No	No
BRAF-SRGAP3	B-Raf, B-raf-1, BRAF1, RAFB1, SRGAP3-BRAF	Yes	No	No	No	No
BRSK1	KIAA1811	Yes	Yes	No	Yes	No
BRSK2	C11orf7, FLJ41362, HUSSY-12, PEN11B, SAD1, STK29	Yes	Yes	No	Yes	No
BTK	AGMX1, AT, ATK, BPK, PSCTK1	Yes	Yes	No	Yes	No
BTK (C481S)	AGMX1, AT, ATK, BPK, PSCTK1	Yes	No	No	Yes	No
BTK (E41K)	AGMX1, AT, ATK, BPK, PSCTK1	Yes	No	No	Yes	No
BTK (P190K)	AGMX1, AT, ATK, BPK, PSCTK1	Yes	No	No	Yes	No
BTK (T474I)	AGMX1, AT, ATK, BPK, PSCTK1	Yes	No	No	No	No
BTK (Y485F)	AGMX1, AT, ATK, BPK, PSCTK1	Yes	No	No	No	No
BUB1B	O60566	No	Yes	No	No	No
CAMK1	CAMK1-PEN, CAMKI	Yes	No	No	Yes	No
CAMK1D	CKLiK, CaM-K1, CaMKID	Yes	Yes	No	Yes	No
CAMK1G	CLICKIII, VWS1, dJ272L16.1	Yes	No	No	Yes	No
CAMK2A	CAMKA, KIAA0968	Yes	Yes	No	Yes	No
CAMK2B	CAM2, CAMK2, CAMKB, MGC29528	Yes	Yes	No	No	No
CAMK2D	CAMKD, MGC44911, CaMKII delta	Yes	Yes	No	Yes	No
CAMK2G	CAMK, CAMK-II, CAMKG, MGC26678	Yes	Yes	No	Yes	No
CAMK4	CaMK-GR, MGC36771	Yes	Yes	No	No	No
CAMKK1	CAMKKA, DKFZp761M0423, MGC34095	Yes	Yes	No	No	No
CAMKK2	CAMKK, CAMKKB, KIAA0787, MGC15254	Yes	Yes	No	No	No
CDC42BPA	MRCK-alpha, MRCKa	Yes	Yes	No	No	No
CDC42BPB	MRCK-beta, MRCKb	Yes	Yes	No	No	No
CDC42BPG	DMPK2, HSMDPKIN, KAPPA-200,	Yes	No	No	No	No
CDC7-DBF4	CDC7L1, HsCdc7, HsCDC7, Hsk1, huCdc7	Yes	Yes	No	No	No
CDK1-CCNA2	CDC2, p34	Yes	Yes	No	No	No
CDK1-CCNB1	CDC2, p34	Yes	Yes	No	Yes	No
CDK1-CCNE1	CDC2, p34	Yes	Yes	No	Yes	No
CDK10-CCNL2	PISSLRE	No	No	No	Yes	No
CDK10-CCNQ	Q15131	No	Yes	No	No	No
CDK11A-CCNK	PITSLRE	No	No	No	Yes	No
CDK11A-CCNL2	PITSLRE	No	No	No	Yes	No
CDK11B-CCNK	P21127	No	Yes	No	No	No
CDK12 (R722C)-CCNK	CRKRS, CRK7	Yes	Yes	No	No	No
CDK12-CCNK	CRKRS, CRK7	Yes	Yes	No	Yes	No
CDK13-CCNK	CDC2L, CDC2L5, CHED	Yes	Yes	No	Yes	No
CDK14-CCNY	PFTAIRE1, PFTK1	Yes	Yes	No	Yes	No
CDK15-CCNA2	Cyclin-dependent kinase 15, Cell division protein kinase 15, PFTK2, CCNA2	Yes	Yes	No	No	No
CDK15-CCNB1	PFTK2, CCNB1	Yes	Yes	No	No	No
CDK15-CCNY	ALS2CR7; PFTK2; PFTAIRE2	No	No	No	Yes	No
CDK16-CCNY	PCTAIRE1, PCTAIRE, PCTGAIRE, PCTK1	Yes	Yes	No	Yes	No
CDK17-CCNY	PCTAIRE2, PCTK2	Yes	No	No	Yes	No
CDK17-CDK5R1	Q00537	No	Yes	No	No	No
CDK18-CCNY	PCTAIRE, PCTAIRE3, PCTK3	Yes	Yes	No	Yes	No
CDK19-CCNC	CDC2L6, CDK11	Yes	Yes	No	Yes	No
CDK2-CCNA1	p33	Yes	No	No	Yes	No
CDK2-CCNA2	p33	Yes	Yes	No	No	No
CDK2-CCND1	P24941	No	Yes	No	No	No
CDK2-CCNE1	p33	Yes	Yes	No	Yes	No
CDK2-CCNE2	p33	Yes	No	No	No	No
CDK2-CCNO	p33	Yes	No	No	No	No
CDK20-CCNH	Q8IZL9	No	Yes	No	Yes	No
CDK20-CCNT1	Q8IZL9	No	Yes	No	No	No
CDK3-CCNC	Cyclin-dependent kinase 3, CCNC	Yes	Yes	No	No	No
CDK3-CCNE1	CDKN3	Yes	Yes	No	Yes	No
CDK3-CCNE2	CDKN3	Yes	No	No	No	No
CDK4-CCND1	CMM3, PSK-J3	Yes	Yes	No	Yes	No
CDK4-CCND2	CMM3, PSK-J3	Yes	Yes	No	No	No
CDK4-CCND3	CMM3, PSK-J3	Yes	Yes	No	Yes	No
CDK5-CDK5R1	PSSALRE	Yes	Yes	No	Yes	No
CDK5-CDK5R1 (p25)	PSSALRE	Yes	Yes	No	No	No
CDK5-CDK5R2	PSSALRE	No	No	No	Yes	No
CDK6-CCND1	PLSTIRE	Yes	Yes	No	Yes	No
CDK6-CCND2	PLSTIRE	Yes	Yes	No	No	No
CDK6-CCND3	PLSTIRE	Yes	Yes	No	Yes	No
CDK7	CAK1, CDKN7, STK1, p39MO15	No	No	No	Yes	No
CDK7-CCNH	CAK1; CDKN7; STK1; p39MO15	No	No	No	Yes	No
CDK7-CCNH-MNAT1	CAK1, CDKN7, STK1, p39MO15	Yes	Yes	No	No	No
CDK8-CCNC	K35	Yes	Yes	No	Yes	No
CDK9-CCNK	C-2k, CDC2L4, PITALRE, TAK, CDC2-related kinase	Yes	Yes	No	Yes	No
CDK9-CCNT1	C-2k, CDC2L4, PITALRE, TAK, CDC2-related kinase	Yes	Yes	No	Yes	No
CDK9-CCNT2	C-2k, CDC2L4, PITALRE, TAK, CDC2-related kinase	Yes	No	No	Yes	No
CDKL1	KKIALRE	No	No	No	Yes	No
CDKL2	KKIAMRE, P56	No	No	No	Yes	No
CDKL3	NKIAMRE	No	No	No	Yes	No
CDKL5	CFAP247, EIEE2	No	No	No	Yes	No
CEP43-FGFR1	FOP, CEP43, FGFR1-FGFR1OP	Yes	No	No	No	No
CHEK1	CHEK1	Yes	Yes	No	Yes	No
CHEK2	CDS1, HuCds1, PP1425, RAD53, bA444G7	Yes	Yes	No	Yes	No
CHEK2 (I157T)	CDS1, HuCds1, PP1425, RAD53, bA444G7	Yes	No	No	No	No
CHUK	IKBKA, IKK1, IKKA, NFKBIKA, TCF16, IKK-alpha, IKKalpha, IKKa	Yes	Yes	No	No	No
CILK1	LCK2, ICK, MRK	Yes	No	No	Yes	No
CIT	CRIK, STK21/CIT	Yes	Yes	No	No	No
CK1a1 (E42C)	CKI-alpha, CK1, KC1A, CSNK1A1	Yes	No	No	No	No
CK1a1 (I35C)	CKI-alpha, CK1, KC1A, CSNK1A1	Yes	No	No	No	No
CLK1	CLK, CLK/STY	Yes	Yes	No	Yes	No
CLK2	MGC61500, hCLK2	Yes	Yes	No	Yes	No
CLK3	PHCLK3, PHCLK3/152, CDc-like kinase 3	Yes	Yes	No	No	No
CLK4	DKFZp686A20267, CDc-like kinase 4	Yes	Yes	No	Yes	No
COQ8B	ADCK4	No	No	No	Yes	No
CSF1R	C-FMS, CD115, CSF-1-R, CSFR, FIM2, FMS, CSF1R	Yes	Yes	No	Yes	No
CSK	CSK	Yes	Yes	No	Yes	No
CSNK1A1	CK1, HLCDGP1, PRO2975, CK1-alpha1, CK1alpha1, CK1a1	Yes	Yes	No	No	No
CSNK1A1L	CK1-alpha1 like	Yes	No	No	Yes	No
CSNK1D	HCKID, CK1-delta, CK1d, CK1delta	Yes	Yes	No	Yes	No
CSNK1E	CKIe, HCKIE, MGC10398, CK1-epsilon	Yes	Yes	No	Yes	No
CSNK1E (R178C)	CKIe, HCKIE, MGC10398, CK1-epsilon	Yes	No	No	No	No
CSNK1G1	CK1-gamma1, CK1gamma1, CK1g1	Yes	Yes	No	No	No
CSNK1G2	CK1g2, CK1-gamma2, CK1gamma2	Yes	Yes	No	Yes	No
CSNK1G3	CK1-gamma3, CK1gamma3	Yes	Yes	No	No	No
CSNK2A1	CKII, CK2A1, CK2-alpha1, CK2alpha1, CK2a	Yes	Yes	No	Yes	No
CSNK2A2	CK2-alpha2, CK2alpha2, CK2a2	Yes	Yes	No	Yes	No
DAPK1	DAPK1	Yes	Yes	No	No	No
DAPK2	DRP-1	Yes	Yes	No	Yes	No
DAPK3	ZIPK/DAPK3, ZIP, ZIPK	Yes	Yes	No	No	No
DCLK1	DCLK, KIAA0369	Yes	No	No	No	No
DCLK2	DCDC3, DCK2, MGC45428, KIAA0369	Yes	Yes	No	No	No
DCLK3	DCAMKL3, DCDC3C	No	No	No	Yes	No
DDR1	CAK, CD167, DDR, EDDR1, MCK10, NEP	Yes	No	No	Yes	No
DDR2	MIG20a, NTRKR3, TKT, TYRO10	Yes	Yes	No	Yes	No
DDR2 (N456S)	MIG20a, NTRKR3, TKT, TYRO10	Yes	Yes	No	Yes	No
DDR2 (T654M)	MIG20a, NTRKR3, TKT, TYRO10	Yes	Yes	No	No	No
DGKA	DAGK1, DAGK, DGK-alpha	Yes	No	No	No	No
DGKB	DAGK2, KIAA0718, DGK-beta	Yes	No	No	No	No
DGKD	DGK-delta, KIAA0145	Yes	No	No	No	No
DGKE	DAGK5, DGK-epsilon	Yes	No	No	No	No
DGKG	DAGK3, DGK-gamma	Yes	No	No	No	No
DGKH	DGK-eta	Yes	No	No	No	No
DGKI	DGK-iota	Yes	No	No	No	No
DGKK	DGK-kappa	Yes	No	No	No	No
DGKQ	DAGK4, DGK-theta	Yes	No	No	No	No
DGKZ	DAGK6, DGK-zeta	Yes	No	No	No	No
DMPK	DMPK1, DM, DM1, DM1PK, DMK	Yes	Yes	No	Yes	No
DSTYK	SgK496, SHIK	Yes	Yes	No	No	No
DYRK1A	DYRK, DYRK1, HP86, MNB, MNBH	Yes	Yes	No	Yes	No
DYRK1B	MIRK	Yes	Yes	No	Yes	No
DYRK2	DYRK2	Yes	Yes	No	Yes	No
DYRK3	DYRK5, RED, REDK	Yes	Yes	No	No	No
DYRK4	DYRK4	Yes	Yes	No	No	No
EEF2K	HSU93850, MGC45041, eEF-2K	Yes	Yes	No	No	No
EGFR	ERBB, mENA, ERBB1	Yes	Yes	Yes	No	Yes
EGFR (A763_Y764insFHEA)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (A763_Y764insFQEA)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (A767_S768insTLA)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (C775S/T790M/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (C797A)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (C797G/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (C797S)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (D761Y)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (D770GY)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (D770_N771insG)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (D770_N771insNPG)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (D770_N771insNPG/T790M)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (G719C)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (G719D)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (G719S)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (K716A)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (K716A/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (K716A/T790M/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (K716Q/L718Q)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (K728A)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (K728A/T790M/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L718Q)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (L747S)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L792F)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L792F/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L792H)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L792H/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L792H/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (L861Q)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (N771_P772insH)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (N771_P772insN)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (R999A)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (S768I)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (T790M)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (T790M/C797G/L858R)	EGFR, ErbB-1, HER1	Yes	No	No	No	No
EGFR (T790M/C797S)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (T790M/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (T790M/L792F/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (T790M/L792F/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (T790M/L792H/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (T790M/L792H/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (T790M/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (V769_D770insGE)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (V948R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d746)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d746-750)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (d746-750/C775S/T790M/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (d746-750/C797A)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d746-750/C797S)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (d746-750/G724S)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d746-750/S768I)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d746-750/T790M)	EGF-R, ERBB, mENA, ERBB1	Yes	No	Yes	No	No
EGFR (d746-750/T790M/C797S)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	Yes
EGFR (d746-750/T790M/C797S/L858R)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d746-750/T790M/L792F)	EGFR, ERBB1, HER1	Yes	No	No	No	No
EGFR (d746-750/T790M/L792H)	EGFR, ERBB1, HER1	Yes	No	No	No	No
EGFR (d746-750/T790M/L798I)	EGFR, ERBB1, HER1	Yes	No	No	No	No
EGFR (d746-750/T790M/L858R)	EGFR, ERBB1, HER1	Yes	No	No	No	No
EGFR (d747-749)	EGF-R, ERBB, mENA, ERBB1	Yes	No	No	No	No
EGFR (d747-749/A750P)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EGFR (d747-752/P753S)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	No	No	No
EGFR (d752-759)	EGF-R, ERBB, mENA, ERBB1	Yes	Yes	Yes	No	No
EIF2AK1	HCR, HRI, EIF2AK1	Yes	Yes	No	No	No
EIF2AK2	PKR, PRKR	Yes	Yes	No	No	No
EIF2AK3	DKFZp781H1925, PEK, PERK, WRS	Yes	Yes	No	No	No
EIF2AK4	GCN2	Yes	Yes	No	Yes	No
EPHA1	EPH, EPHT, EPHT1	Yes	Yes	No	Yes	No
EPHA2	ECK	Yes	Yes	No	Yes	No
EPHA3	ETK, ETK1, HEKECK, HEK4, TYRO4	Yes	Yes	No	Yes	No
EPHA4	HEK8, SEK, TYRO1	Yes	Yes	No	Yes	No
EPHA5	CEK7, EHK1,HEK7,	Yes	Yes	No	Yes	No
EPHA6	EHK2, EHK-2, EPA6	Yes	Yes	No	Yes	No
EPHA7	EHK3, HEK11	Yes	Yes	No	Yes	No
EPHA8	EEK, HEK3, KIAA1459	Yes	Yes	No	Yes	No
EPHB1	ELK, NET, Hek6, EPHT2	Yes	Yes	No	Yes	No
EPHB2	DRT, ERK, Hek5, EPHT3, Tyro5	Yes	Yes	No	Yes	No
EPHB3	ETK2, HEK2, TYRO6	Yes	Yes	No	Yes	No
EPHB4	HTK, MYK1, TYRO11	Yes	Yes	Yes	Yes	No
ERBB2	NEU, NGL, HER2, TKR1	Yes	Yes	Yes	No	No
ERBB2 (775YVMA776)	P04626	No	Yes	No	No	No
ERBB2 (A775_G776insYVMA)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (D769H)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (D769Y)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (P1170A)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (P780-Y781insGSP)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (R896C)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (V777L)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (V777_G778insCG)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB2 (V956R)	NEU, NGL, HER2, TKR1	Yes	No	No	No	No
ERBB4	HER4	Yes	Yes	Yes	No	No
ERN1	IRE1	Yes	No	No	Yes	No
ERN1 (R727A)	IRE1	Yes	No	No	No	No
ERN1 (R728A)	IRE1	Yes	No	No	No	No
ERN1/IRE1 (R727A/R728A)	IRE1	Yes	No	No	No	No
ERN2	IRE2	Yes	No	No	Yes	No
FER	TYK3, c-FER, p94-FER	Yes	Yes	No	Yes	No
FES	FPS	Yes	Yes	No	Yes	No
FGFR1	H2, H3, H4, H5, CEK, FLG, FLT2, KAL2, BFGFR, C-FGR, N-SAM	Yes	Yes	No	Yes	No
FGFR1 (V561M)	H2, H3, H4, H5, CEK, FLG, FLT2, KAL2, BFGFR, C-FGR, N-SAM	Yes	Yes	No	No	No
FGFR1 (W666R)	FGFR-1, bFGF-R, FLT2, c-fgr	Yes	No	No	No	No
FGFR2	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	Yes	Yes	Yes	No
FGFR2 (C491A)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (C491A/V564I)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (C491A/V564L)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (C491F)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (C491S)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (C491S/V564L)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (E565A)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (E565G)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (K526E)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (K641R)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (K659N)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (M420I)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (N549H)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (N549K)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (R612T)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (V564F)	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, KSAM, K-SAM, TK14, TK25	Yes	No	No	No	No
FGFR2 (V564I)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR2 (V564L)	Fibroblast growth factor receptor 2 [Precursor], Keratinocyte growth factor receptor 2	Yes	No	No	No	No
FGFR3	ACH, CD333, CEK2, HSFGFR3EX, JTK4	Yes	Yes	No	Yes	No
FGFR3 (G697C)	ACH, CD333, CEK2, HSFGFR3EX, JTK4	Yes	Yes	No	Yes	No
FGFR3 (K650E)	ACH, CD333, CEK2, HSFGFR3EX, JTK4	Yes	Yes	No	No	No
FGFR3 (K650M)	ACH, CD333, CEK2, HSFGFR3EX, JTK4	Yes	Yes	No	No	No
FGFR3 (K650Q)	ACH, CD333, CEK2, HSFGFR3EX, JTK4	Yes	No	No	No	No
FGFR3 (V555M)	ACH, CD333, CEK2, HSFGFR3EX, JTK4	Yes	No	No	No	No
FGFR4	TKF, JTK2, MGC20292	Yes	Yes	No	Yes	No
FGFR4 (N535K)	TKF, JTK2, MGC20292	Yes	Yes	No	No	No
FGFR4 (V550E)	TKF, JTK2, MGC20292	Yes	Yes	No	No	No
FGFR4 (V550L)	TKF, JTK2, MGC20292	Yes	No	No	No	No
FGFR4 (V550M)	TKF, JTK2, MGC20292	Yes	No	No	No	No
FGR	SRC2, c-fgr, p55c-fgr	Yes	Yes	No	Yes	No
FLT1	FLT, VEGFR1, FLT1, VEGF-R1	Yes	Yes	No	Yes	No
FLT3	FLK2, STK1, CD135	Yes	Yes	Yes	Yes	No
FLT3 (D835H)	FLK2; STK1; CD135	No	No	No	Yes	No
FLT3 (D835V)	FLK2; STK1; CD135	No	No	No	Yes	No
FLT3 (D835Y)	FLK2, STK1, CD135	Yes	Yes	Yes	Yes	No
FLT3 (F594_R595insR)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (F594_R595insREY)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (F691L/D835Y)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (ITD)	FLK2, STK1, CD135	Yes	Yes	Yes	No	No
FLT3 (ITD)-NPOS	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (ITD)-W51	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (K663Q)	FLK2; STK1; CD135	No	No	No	Yes	No
FLT3 (N841I)	FLK2; STK1; CD135	No	No	No	Yes	No
FLT3 (R595_E596insEY)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (R834Q)	FLK2; STK1; CD135	No	No	No	Yes	No
FLT3 (Y591-V592insVDFREYEYD/D835Y)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (Y591-V592insVDFREYEYD/F691L)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT3 (Y591_V592insVDFREYEYD)	FLK2, STK1, CD135	Yes	No	No	No	No
FLT4	VEGFR3, PCL, VEGF-R3	Yes	Yes	Yes	No	No
FRK	PTK5, GTK, RAK	Yes	Yes	No	Yes	No
FYN	SLK, SYN, p59-Fyn	Yes	Yes	Yes	Yes	No
FYN (Y531F)	SLK, SYN, p59-Fyn	Yes	Yes	No	Yes	No
GAK	DNAJC26	No	No	No	Yes	No
GRK1	RHOK	Yes	No	No	No	No
GRK2	ADRBK1	Yes	Yes	No	No	No
GRK3	ADRBK2	Yes	Yes	No	No	No
GRK4	GPRK2L, GPRK4, GRK4a, IT11	Yes	Yes	No	No	No
GRK5	GPRK5	Yes	Yes	No	No	No
GRK6	GPRK6, FLJ32135	Yes	Yes	No	No	No
GRK7	GPRK7	Yes	Yes	No	No	No
GSG2	GSG2, Haspin	Yes	Yes	Yes	No	No
GSK3A	GSK3alpha, GSK3a	Yes	Yes	No	Yes	No
GSK3B	GSK3beta, GSK3b	Yes	Yes	No	Yes	No
HCK	JTK9	Yes	Yes	No	Yes	No
HIPK1	KIAA0630, MGC26642, MGC33446, Myak, Nbak2	Yes	Yes	No	No	No
HIPK2	PRO0593	Yes	Yes	No	Yes	No
HIPK3	ANPK, DYRK6, FIST, FIST3, PKY, YAK1	Yes	Yes	No	Yes	No
HIPK4	FLJ32818	Yes	Yes	No	Yes	No
HUNK	HUNK	No	No	No	Yes	No
IGF1R	JTK13, IGFR, CD221	Yes	Yes	Yes	Yes	No
IKBKB	IKK2, IKKB, NFKBIKB, IKK-beta, IKKbeta	Yes	Yes	No	No	No
IKBKE	IKKI, IKK-i, KIAA0151, IKK-epsilon, IKKepsilon	Yes	Yes	No	Yes	No
INSR	IR	Yes	Yes	No	Yes	No
INSRR	IRR	Yes	Yes	No	No	No
IRAK1	Pelle	Yes	Yes	No	Yes	No
IRAK2	Interleukin-1 receptor-associated kinase-like 2	Yes	No	No	No	No
IRAK3	IRAK-M	No	No	No	Yes	No
IRAK4	REN64	Yes	Yes	No	Yes	No
IRAK4 (aa104-460) untagged	Q9NWZ3	No	Yes	No	No	No
ITK	EMT 2, LYK 2, PSCTK2 2	Yes	Yes	No	Yes	No
JAK1	P23458	No	Yes	No	No	No
JAK1 (S729C)	P23458	No	Yes	No	No	No
JAK1 (aa850-1154)	P23458	No	Yes	No	No	No
JAK1 (aa866-1154)	JAK1A, JAK1B, JTK3	Yes	No	No	No	No
JAK2	JAK2	Yes	Yes	No	Yes	No
JAK2 (JH1&2)	JAK2	Yes	No	No	No	No
JAK2 (JH1)	JAK2	No	No	No	Yes	No
JAK2 (V617F)	JAK2	Yes	No	No	Yes	No
JAK3	JAKL, L-JAK, LJAK	Yes	Yes	No	Yes	No
KDR	VEGFR2, FLK1, VEGF-R2	Yes	Yes	Yes	No	No
KIT	C-Kit, PBT, CD117, SCFR,	Yes	Yes	Yes	Yes	No
KIT (A829P)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	Yes	No
KIT (D816E)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	No	No
KIT (D816F)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (D816H)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	Yes	No
KIT (D816I)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (D816V)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	Yes	No
KIT (D816Y)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (D820E)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (D820Y)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (K642E)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (L576P)	PBT; CD117; SCFR; c-KIT	No	No	No	Yes	No
KIT (N822K)	Mast/stem cell growth factor receptor, Proto-oncogene tyrosine-protein kinase c-kit	Yes	No	No	No	No
KIT (T670I)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	No	No
KIT (V559A)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (V559D)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	Yes	No
KIT (V559D/T670I)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	Yes	No
KIT (V559D/V654A)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	Yes	No
KIT (V560G)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	No	No
KIT (V560G/D816V)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (V560G/N822K)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (V654A)	C-Kit, PBT, CD117, SCFR,	Yes	Yes	No	No	No
KIT (Y823D)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (d557-558)	C-Kit, PBT, CD117, SCFR,	Yes	No	No	No	No
KIT (d557-558/Y823D)	C-Kit, PBT, CD117, SCFR	Yes	No	No	No	No
KSR1	Kinase suppressor of Ras 1	Yes	No	No	No	No
KSR1 (A635F)	Kinase suppressor of Ras 1	Yes	No	No	No	No
KSR1 (L639F)	Kinase suppressor of Ras 1	Yes	No	No	No	No
KSR2	Kinase suppressor of Ras 2	Yes	No	No	No	No
KSR2 (R676S)	Kinase suppressor of Ras 2	Yes	No	No	No	No
LATS1	WARTS, wts	Yes	No	No	Yes	No
LATS2	FLJ13161, LATS	Yes	No	No	Yes	No
LCK	LCK	Yes	Yes	No	Yes	No
LIMK1	LIMK	Yes	Yes	No	Yes	No
LIMK2	LIMK2	Yes	Yes	No	Yes	No
LRRK2	PARK8, ROCO2, FLJ45829, DKFZp434H2111	Yes	Yes	Yes	Yes	No
LRRK2 (G2019S)	PARK8, ROCO2, FLJ45829, DKFZp434H2111	Yes	Yes	No	Yes	No
LRRK2 (I2020T)	PARK8, ROCO2, FLJ45829, DKFZp434H2111	Yes	Yes	No	Yes	No
LRRK2 (R1441C)	PARK8, ROCO2, FLJ45829, DKFZp434H2111	Yes	Yes	No	Yes	No
LTK	TYK1	Yes	Yes	No	Yes	No
LYN	JTK8	Yes	Yes	No	Yes	No
LYN (d23-43)	JTK8	Yes	No	No	No	No
MAK	MAK	Yes	No	No	No	No
MAP2K1	MAPKK1, MKK1, PRKMK1	Yes	Yes	No	No	No
MAP2K1 (F53L)	Q02750	No	Yes	No	No	No
MAP2K1 (P124L)	MAPKK1, MKK1, PRKMK1	Yes	Yes	No	No	No
MAP2K1 (S218E/S222E)	Q02750	No	Yes	No	No	No
MAP2K1/KRAS(G12C)	MEK1, MAPKK1, MKK1, PRKMK1	No	No	No	Yes	No
MAP2K1/MAP2K2	PANC-1	No	No	Yes	No	No
MAP2K2	MAPKK2, MKK2, PRKMK2	Yes	Yes	No	No	No
MAP2K2/KRAS(G12C)	MEK2, MAPKK2, MKK2, PRKMK2	No	No	No	Yes	No
MAP2K3	MEK3	Yes	No	No	No	No
MAP2K4	JNKK, JNKK1, MAPKK4, MEK4, PRKMK4, SEK, SERK1	Yes	Yes	No	No	No
MAP2K5	MAPKK5, MKK5, PRKMK5	Yes	Yes	No	No	No
MAP2K6	MAPKK6, MEK6, PRKMK6, SAPKK3	Yes	No	No	Yes	No
MAP2K6 (S207D/T211D)	P52564	No	Yes	No	No	No
MAP2K7	MAPKK7, MEK7, PRKMK7	Yes	Yes	No	No	No
MAP3K1	MAPKKK1, MEKK, MEKK1	Yes	Yes	No	No	No
MAP3K10	MLK2, MST, MEKK10	Yes	Yes	No	Yes	No
MAP3K11	MGC17114, MLK-3, PTK1, SPRK, MLK3	Yes	Yes	No	Yes	No
MAP3K12	DLK	Yes	No	No	Yes	No
MAP3K13	LZK, MEKK13	No	No	No	Yes	No
MAP3K14	NIK, FTDCR1B, HS, HSNIK	Yes	Yes	No	No	No
MAP3K19	M3K19, RCK, YSK4	Yes	No	No	Yes	No
MAP3K2	MAPKKK2, MEKK2B	Yes	Yes	No	Yes	No
MAP3K20	MLTK, mlklak, ZAK	Yes	Yes	No	Yes	No
MAP3K21	KIAA1804	Yes	Yes	No	Yes	No
MAP3K3	MAPKKK3, MEK kinase3	Yes	Yes	No	Yes	No
MAP3K4	MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412	No	No	No	Yes	No
MAP3K5	ASK1, MAPKKK5, MEKK5	Yes	Yes	No	No	No
MAP3K6	ASK2, MAPKKK6	Yes	No	No	No	No
MAP3K7	MAP3K7, TGF1a, MEKK7, TAK1	Yes	No	No	No	No
MAP3K7-TAB1	O43318	No	Yes	No	No	No
MAP3K8	COT1, EST, ESTF, TPL2, Tpl-2, COT	Yes	Yes	No	No	No
MAP3K9	MLK1, PRKE1, MEKK9	Yes	Yes	No	Yes	No
MAP4K1	HPK1	Yes	Yes	Yes	Yes	No
MAP4K2	BL44, GCK, RAB8IP	Yes	Yes	No	Yes	No
MAP4K3	GLK	Yes	No	No	Yes	No
MAP4K4	HGK	Yes	Yes	No	No	No
MAP4K5	KHS1, GCKR, KHS, MAPKKKK5	Yes	Yes	No	Yes	No
MAPK1	ERK2, ERT1, P42MAPK, PRKM1,	Yes	Yes	No	Yes	No
MAPK1/KRAS(G12C)	ERK2; ERT1; P42MAPK; PRKM1	No	No	No	Yes	No
MAPK10	JNK3A, PRKM10, p493F12	Yes	Yes	No	Yes	No
MAPK11	p38-beta, P38BETA2, PRKM11, SAPK2, p38beta, p38b	Yes	Yes	No	Yes	No
MAPK12	p38-gamma, ERK3, ERK5, ERK6, p38gamma, p38g	Yes	Yes	No	No	No
MAPK13	p38-delta, PRKM13, SAPK4, p38delta, p38d	Yes	Yes	No	No	No
MAPK14	p38-alpha, CSBP, CSBP1, p38alpha, p38a	Yes	Yes	No	Yes	No
MAPK14 (T106M)	p38-alpha, CSBP, CSBP1, p38alpha, p38a	Yes	No	No	Yes	No
MAPK15	ERK8	Yes	Yes	No	No	No
MAPK3	ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3	Yes	Yes	No	Yes	No
MAPK3/KRAS(G12C)	ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3	No	No	No	Yes	No
MAPK4	PRKM4; Erk3-relatedErk4	No	No	No	Yes	No
MAPK6	PRKM6; ERK3p97MAPKHsT17250	No	No	No	Yes	No
MAPK7	BMK1, PRKM7	Yes	No	No	No	No
MAPK7 (CD)	BMK1, PRKM7	Yes	No	No	No	No
MAPK7 (aa5-397)	Q13164	No	Yes	No	No	No
MAPK8	PRKM8, SAPK1, JNK1-alpha1	Yes	Yes	No	Yes	No
MAPK9	PRKM9, SAPK, p54a, JNK-alpha2, JNK2A, JNK2B	Yes	Yes	No	Yes	No
MAPKAPK2	MAPKAPK2	Yes	Yes	No	No	No
MAPKAPK3	3PK, MAPKAP, MAPKAP3	Yes	Yes	No	No	No
MAPKAPK5	PRAK	Yes	Yes	No	No	No
MARK1	KIAA1477	Yes	Yes	No	No	No
MARK2	EMK1, MGC99619, PAR-1Ba, ELKL	Yes	Yes	No	Yes	No
MARK3	CTAK1, KP78, PAR1A	Yes	Yes	No	Yes	No
MARK4	KIAA1860, MARKL1	Yes	Yes	No	Yes	No
MAST3	Microtubule-associated serine/threonine-protein kinase 3, KIAA0561	Yes	No	No	Yes	No
MAST4	KIAA0303	No	No	No	Yes	No
MASTL	GLW, GREATWALL, GWL, hGWL, THC2	Yes	Yes	No	No	No
MATK	CHK, CTK, DKFZp434N1212, HHYLTK, HYL, Lsk, MGC1708, MGC2101	Yes	Yes	No	No	No
MELK	KIAA0175, PK38	Yes	Yes	No	Yes	No
MELK (T460M)	KIAA0175, PK38	Yes	No	No	Yes	No
MERTK	MER, MER-PEN, RP38, c-MER	Yes	Yes	No	Yes	No
MERTK (A708S)	MER, MER-PEN, RP38, c-MER	Yes	No	No	Yes	No
MET	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (D1228A)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (D1228G)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (D1228H)	c-MET, HGFR, RCCP2	Yes	Yes	No	Yes	No
MET (D1228N)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (D1228V)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (D1228Y)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (D1288H)	Rat1	No	No	Yes	No	No
MET (DelEx14)	c-Met, HGFR, MET	Yes	No	No	No	No
MET (F1200I)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (G1163R)	c-MET, HGFR, RCCP2	Yes	Yes	No	No	No
MET (H1094L)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (H1094Y)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (K1244R)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (L1195F)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (L1195V)	c-MET, HGFR, RCCP2	Yes	Yes	No	No	No
MET (M1250I)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (M1250T)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (P991S)	c-MET, HGFR, RCCP2	Yes	No	No	Yes	No
MET (R970C)	c-Met, HGFR, MET	Yes	No	No	No	No
MET (T1173I)	c-MET, HGFR, RCCP2	Yes	No	No	Yes	No
MET (T992I)	c-MET, HGFR, RCCP2	Yes	No	No	Yes	No
MET (V1092I)	c-MET, HGFR, RCCP2	Yes	No	No	Yes	No
MET (Y1230A)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (Y1230C)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (Y1230D)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (Y1230H)	c-MET, HGFR, RCCP2	Yes	Yes	Yes	Yes	No
MET (Y1230S)	c-MET, HGFR, RCCP2	Yes	No	No	No	No
MET (Y1235D)	c-MET, HGFR, RCCP2	Yes	Yes	No	Yes	No
MET-KIF5B	c-MET, HGFR, RCCP2, KIF5B-MET	Yes	No	No	No	No
MET-TFG	c-MET, HGFR, RCCP2, TGF-MET	Yes	No	No	No	No
MINK1	B55, YSK2, MAP4K6, ZC3, MINK	Yes	Yes	No	No	No
MKNK1	MNK1	Yes	Yes	Yes	No	No
MKNK2	MNK2	Yes	Yes	No	Yes	No
MOK	RAGE	No	No	No	Yes	No
MST1R	CD136, CDw136, PTK8, RON	Yes	Yes	Yes	Yes	No
MTOR	FRAP1, FRAP, FRAP2, RAFT1, RAPT1	Yes	Yes	No	No	No
MUSK	MUSK	Yes	Yes	No	Yes	No
MYLK	smMLCK, FLJ12216, KRP, MLCK, MLCK108, MLCK210	Yes	Yes	No	No	No
MYLK2	KMLC, skMLCK, MLCK2	Yes	Yes	No	Yes	No
MYLK3	caMLCK, MLCK	Yes	Yes	No	Yes	No
MYLK4	Myosin light chain kinase family member 4	Yes	No	No	Yes	No
MYO3A	Myosin-IIIa	Yes	No	No	No	No
MYO3B	MYO3b	Yes	No	No	No	No
NEK1	KIAA1901, NY-REN-55,	Yes	Yes	No	Yes	No
NEK11	FLJ23495	Yes	Yes	No	Yes	No
NEK2	NLK1, HsPK21, HsPK 21	Yes	Yes	No	Yes	No
NEK3	HSPK36, MGC29949	Yes	Yes	No	Yes	No
NEK4	NRK2, STK2	Yes	Yes	No	Yes	No
NEK5	MGC75495	Yes	No	No	Yes	No
NEK6	SID6-1512	Yes	Yes	No	Yes	No
NEK7	NEK7	Yes	Yes	No	No	No
NEK8	NEK8	Yes	No	No	No	No
NEK9	DKFZp434D0935, MGC16714, NERCC,	Yes	Yes	No	Yes	No
NIM1K	NIM1	Yes	No	No	Yes	No
NLK	NLK	Yes	Yes	No	Yes	No
NRK	NESK	No	No	No	Yes	No
NTRK1	MTC, TRK, TRK1	Yes	Yes	No	Yes	No
NTRK1 (A608D)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (F589L)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G595R)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G595R/A608D)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G595R/G667A)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G595R/G667C)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G595R/G667S)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G595R/L657M)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (G667C)	MTC, TRK, TRK1	Yes	Yes	No	Yes	No
NTRK1 (G667S)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1 (L657M)	MTC, TRK, TRK1	Yes	No	No	No	No
NTRK1-TFG	TRKA, TGF-NTRK1	Yes	No	No	No	No
NTRK1-TPM3	TRKA, TPM3-NTRK1	Yes	No	No	No	No
NTRK1-TPR	TRKA, TPR-NTRK1	Yes	No	No	No	No
NTRK2	GP145-TrkB	Yes	Yes	No	Yes	No
NTRK3	GP145-TrkC	Yes	Yes	No	No	No
NTRK3 (G623E)	GP145-TrkC	Yes	No	No	No	No
NTRK3 (G623R)	GP145-TrkC	Yes	No	No	No	No
NTRK3 (G623R/L686M)	GP145-TrkC	Yes	No	No	No	No
NTRK3 (G696A)	GP145-TrkC	Yes	No	No	No	No
NTRK3 (L686M)	GP145-TrkC	Yes	No	No	No	No
NUAK1	KIAA0537, ARK5	Yes	Yes	No	Yes	No
NUAK2	SNARK, DKFZp434J037	Yes	Yes	No	Yes	No
OXSR1	OSR1, KIAA1101	Yes	No	No	No	No
PAK1	PAKalpha	Yes	Yes	No	No	No
PAK2	PAK65, PAKgamma	Yes	Yes	No	No	No
PAK2 (Y443N)	PAK-2, PAK65, Gamma-PAK, S6/H4 kinase	Yes	No	No	No	No
PAK3	MRX30, OPHN3, PAK3beta, bPAK	Yes	Yes	No	No	No
PAK4	PAK4	Yes	Yes	No	Yes	No
PAK5	PAK7, PAK5, KIAA1264, MGC26232	Yes	Yes	No	Yes	No
PAK6	PAK6, PAK5	Yes	Yes	No	Yes	No
PASK	DKFZP434O051, DKFZp686P2031, KIAA0135, PASKIN, STK3	Yes	Yes	No	No	No
PBK	TOPK, SPK, Nori-3, FLJ14385	Yes	Yes	No	No	No
PDGFRA	PDGFRalpha, PDGFR2, CD140a	Yes	Yes	No	No	No
PDGFRA (D842V)	PDGFRalpha, PDGFR2, CD140a	Yes	Yes	No	No	No
PDGFRA (G680R)	PDGFRalpha, PDGFR2, CD140a	Yes	No	No	No	No
PDGFRA (T674I)	PDGFRalpha, PDGFR2, CD140a	Yes	Yes	No	No	No
PDGFRA (V561D)	PDGFRalpha, PDGFR2, CD140a	Yes	Yes	No	Yes	No
PDGFRA-FIP1L1	PDGFRalpha, PDGFR2, CD140a, FIP1L1-PDGFRA	Yes	No	No	No	No
PDGFRB	PDGFRbeta, JTK12, PDGFR, CD140B, PDGFR1	Yes	Yes	Yes	No	No
PDGFRB-TPM3	PDGFRbeta, JTK12, PDGFR, CD140B, PDGFR1, TPM3-PDGFRB	Yes	No	No	No	No
PDK1	PDHK1, Pyruvate dehydrogenase kinase	Yes	Yes	No	No	No
PDK2	PDHK2	Yes	No	No	No	No
PDK3	PDHK3	Yes	No	No	No	No
PDK4	PDHK4	Yes	No	No	No	No
PDPK1	PDK1, PKB-like, 3-phosphoinositide-dependent protein kinase 1	Yes	No	No	No	No
PEAK1	PEAK1, KIAA2002	Yes	No	No	No	No
PHKG1	PHKg1	Yes	Yes	No	Yes	No
PHKG2	PHKg2	Yes	Yes	No	Yes	No
PI3KC2B	P3C2B, PIK3C2B, C2-PI3K	Yes	No	No	No	No
PI4K2A	PI4KII, PIK42A, RP11-548K23.6	Yes	Yes	No	No	No
PI4K2B	Q8TCG2	No	Yes	No	No	No
PI4KA	PIK4CA	Yes	No	No	No	No
PI4KB	PIK4CB, NPIK	Yes	Yes	No	No	No
PIK3C2A	CPK, MGC142218, PI3-K-C2A	Yes	Yes	No	No	No
PIK3C2B	O00750	No	Yes	No	No	No
PIK3C2G	O75747	No	Yes	No	No	No
PIK3C3	MGC61518, PI3-kinase type 3, PI3K type 3, Vps34	Yes	Yes	No	Yes	No
PIK3CA (C420R)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA (E542K)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	Yes	No	No	Yes	No
PIK3CA (E545A)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA (E545K)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	Yes	No	No	Yes	No
PIK3CA (H1047L)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA (H1047R)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	Yes	No	No	Yes	No
PIK3CA (H1047Y)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA (I800L)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA (M1043I)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA (Q546K)-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	No	No	No	Yes	No
PIK3CA-PIK3R1	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	Yes	Yes	No	Yes	No
PIK3CA-PIK3R1/p65a	MGC142161, MGC142163, p110-alpha, PI3K, PI3K-alpha	Yes	No	No	No	No
PIK3CB (D1067A)-PIK3R1	P42338	No	Yes	No	No	No
PIK3CB (D1067V)-PIK3R1	P42338	No	Yes	No	No	No
PIK3CB (D1067Y)-PIK3R1	P42338	No	Yes	No	No	No
PIK3CB (E1051K)-PIK3R1	P42338	No	Yes	No	No	No
PIK3CB (E633K)-PIK3R1	P42338	No	Yes	No	No	No
PIK3CB-PIK3R1	PI3K, PI3KBETA, PIK3C1, p110-beta	Yes	Yes	No	Yes	No
PIK3CD-PIK3R1	p110D, P110DELTA, PI3K, PI3K-delta, p110-delta	Yes	Yes	No	Yes	No
PIK3CG	p120-PI3K, PI3CG, PI3K, PI3Kgamma, p110-gamma	Yes	Yes	No	No	No
PIK3CG (L1049R)-PIK3R1	P42338	No	Yes	No	No	No
PIKFYVE	MGC40423, PIP5K, PIP5K3, ZFYVE29, FAB1, KIAA0981	No	No	No	Yes	No
PIM1	PIM	Yes	Yes	Yes	No	No
PIM2	PIM2	Yes	Yes	Yes	No	No
PIM3	PIM3	Yes	Yes	Yes	Yes	No
PIP4K2A	PI42A, PI5P4KA, PIP5K2, PIP5K2A, PIP5KIII	Yes	No	No	No	No
PIP4K2B	PI42B, PIP5K2B	Yes	No	No	No	No
PIP4K2C	PI42C, PIP5K2C	Yes	No	No	Yes	No
PIP5K1A	PIP5K1-alpha, PIP5KIalpha, PtdIns(4)P-5-kinase 1 alpha	Yes	Yes	No	No	No
PIP5K1B	O14986	No	Yes	No	Yes	No
PIP5K1C	PIP5K1-gamma, PIPKIg_v4	Yes	Yes	No	No	No
PKD2/PRKD2 (G848E)	nPKC-D2, KPCD2, PRKD2	Yes	No	No	No	No
PKMYT1	MYT1	Yes	No	No	Yes	No
PKN1	DBK, PKN, PAK1, PRK1, PRKCL1, MGC46204, PKN1	Yes	Yes	No	No	No
PKN1-ANXA4 (Aex2Pex13)	PKN, PRK1, PRKCL1, Annexin A4	Yes	No	No	No	No
PKN1-TECR	DBK, PKN, PAK1, PRK1, PRKCL1, MGC46204, TECR-PKN1, PKN1	Yes	No	No	No	No
PKN2	PRK2, PRKCL2, PAK-2	Yes	Yes	No	No	No
PKN3	PRK3, PKNbeta, RP11-545E17.1	Yes	Yes	No	No	No
PLK1	STPK13	Yes	Yes	No	Yes	No
PLK2	SNK	Yes	Yes	No	Yes	No
PLK3	CNK, FNK, PRK	Yes	Yes	No	Yes	No
PLK4	SAK, STK18	Yes	Yes	No	Yes	No
PNCK	CAMK1b, MGC45419	Yes	No	No	No	No
PRKAA1	Q13131	No	Yes	No	Yes	No
PRKAA1 (aa1-312)	Q13131	No	Yes	No	No	No
PRKAA1-PRKAB1-PRKAG1	AMPK (A1/B1/G1)	Yes	No	No	No	No
PRKAA1-PRKAB1-PRKAG2	AMPK (A1/B1/G2)	Yes	No	No	No	No
PRKAA1-PRKAB1-PRKAG3	AMPK (A1/B1/G3)	Yes	No	No	No	No
PRKAA1-PRKAB2-PRKAG1	AMPK (A1/B2/G1)	Yes	No	No	No	No
PRKAA1-PRKAB2-PRKAG2	AMPK (A1/B2/G2)	Yes	No	No	No	No
PRKAA1-PRKAB2-PRKAG3	AMPK (A1/B2/G3)	Yes	No	No	No	No
PRKAA2	AMPK; AMPKa2	No	No	No	Yes	No
PRKAA2-PRKAB1-PRKAG1	AMPK (A2/B1/G1)	Yes	No	No	No	No
PRKAA2-PRKAB1-PRKAG2	AMPK (A2/B1/G2)	Yes	No	No	No	No
PRKAA2-PRKAB1-PRKAG3	AMPK (A2/B1/G3)	Yes	No	No	No	No
PRKAA2-PRKAB2-PRKAG1	AMPK (A2/B2/G1)	Yes	No	No	No	No
PRKAA2-PRKAB2-PRKAG2	AMPK (A2/B2/G2)	Yes	No	No	No	No
PRKAA2-PRKAB2-PRKAG3	AMPK (A2/B2/G3)	Yes	No	No	No	No
PRKACA	PKACa	Yes	Yes	No	Yes	No
PRKACA (L206R)	PKACa	Yes	No	No	No	No
PRKACA-DNAJB1	PKACa, Hsp40, Sis1, RSPH16B	Yes	No	No	No	No
PRKACB	PKAcb, MGC41879, MGC9320, PKA c-beta	Yes	No	No	Yes	No
PRKACG	PKAcg	Yes	No	No	No	No
PRKCA	PRKACA, PKc-alpha, PKCa, PKCalpha	Yes	Yes	No	No	No
PRKCB (1)	PRKCB1, PKCB, PRKCB2, MGC41878, PKC-beta, PKC-beta1, PKCb1, PKCbeta1	Yes	Yes	No	No	No
PRKCB (2)	PRKCB1, PKCB, PRKCB2, MGC41878, PKC-beta, PKC-beta2, PKCb2, PKCbeta2	Yes	Yes	No	No	No
PRKCD	MAY1, MGC49908, nPKC-delta, PKC-delta, PKCd, PKCdelta	Yes	Yes	No	No	No
PRKCE	PKCE, nPKC-epsilon, PKC-epsilon	Yes	Yes	No	Yes	No
PRKCG	PKCC, PKCG, SCA14, MGC57564, PKC-gamma, PKCgamma	Yes	Yes	No	No	No
PRKCH	PKC-L, PKCL, PRKCL, nPKC-eta	Yes	Yes	No	No	No
PRKCI	PKCI, DXS1179E, MGC26534, nPKC-iota	Yes	Yes	No	No	No
PRKCQ	PRKCT, nPKC-theta	Yes	Yes	No	No	No
PRKCZ	PKC2, PKCzeta	Yes	Yes	No	No	No
PRKCZ (aa184-592)	nPKC-zeta, PKC2, PKMzeta	Yes	Yes	No	No	No
PRKD1	PKD1, PKD, PKCM, PKc-MU	Yes	Yes	No	No	No
PRKD2	PKD2, HSPC187	Yes	Yes	No	No	No
PRKD2 (G870E)	PKD2, HSPC187	Yes	No	No	No	No
PRKD3	PKD3, EPK2, PKc-NU, PKD3, PRKCN	Yes	Yes	No	No	No
PRKDC	DNPK1, HYRC, p350, DNAPK, DNA-PK	Yes	Yes	No	No	No
PRKG1 (a)	PKG1, PGK, PRKG1B, PRKGR1B	Yes	Yes	No	No	No
PRKG1 (b)	PKG1, PGK, PRKG1B, PRKGR1B	Yes	No	No	No	No
PRKG2	PKG2, cGKII, PRKGR2	Yes	Yes	No	Yes	No
PRKX	PKX1	Yes	Yes	No	Yes	No
PTK2	FAK, FADK	Yes	Yes	Yes	Yes	No
PTK2 (aa411-686)	Q05397	No	Yes	No	No	No
PTK2B	CADTK, CAKB, FADK2, FAK2, PKB, PTK, RAFTK, CAK beta	Yes	Yes	No	Yes	No
PTK6	BRK	Yes	Yes	No	Yes	No
RAF1 (R391W)	c-RAF	Yes	No	No	No	No
RAF1 (Y340/Y341D)	P04049	No	Yes	No	No	No
RAF1 (Y340D/Y341D)	c-RAF	Yes	No	No	No	No
RET	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	Yes	No
RET (A883F)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (E732K)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (E762Q)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (G691S)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (G810C)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (G810R)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (G810S)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (L730I)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (L730M)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (L790F)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (M918T)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	Yes	No
RET (R749T)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (R813Q)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (R912P)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (S891A)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (S904A)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (S904F)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (V738A)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (V778I)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (V804E)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (V804L)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	Yes	No
RET (V804L)-KIF5B	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, KIF5B-RET (V804L)	Yes	No	No	No	No
RET (V804M)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	Yes	No
RET (V804M)-KIF5B	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, KIF5B-RET (V804M)	Yes	No	No	No	No
RET (Y791F)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (Y806C)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET (Y806H)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	Yes	No	No	No
RET (Y806N)	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51	Yes	No	No	No	No
RET-BCR	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, BCR-RET	Yes	No	No	No	No
RET-CCDC6	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, CCDC6-RET	Yes	Yes	No	No	No
RET-KIF5B	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, KIF5B-RET	Yes	No	No	No	No
RET-NCOA4	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, NCOA4-RET	Yes	No	No	No	No
RET-PRKARA1A	CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, PRKARA1A-RET	Yes	No	No	No	No
RIOK2	FLJ11159	No	No	No	Yes	No
RIPK1	RIP	No	No	No	Yes	No
RIPK2	CARD3, CARDIAK, CCK, GIG30, RICK, RIP-2, RIP2	Yes	Yes	No	Yes	No
RIPK3	RIP3, receptor interacting protein 3	Yes	No	No	No	No
RIPK4	Receptor interacting protein kinase 4, ANKK2, ANKRD3, DIK, MGC129992, MGC129993, PKK	Yes	Yes	No	No	No
ROCK1	P160ROCK	Yes	Yes	No	Yes	No
ROCK1 and ROCK2	A7r5	No	No	Yes	No	No
ROCK2	KIAA0619, ROC2	Yes	Yes	No	Yes	No
ROS1	ROS, MCF3	Yes	Yes	No	No	No
ROS1 (G2032R)	ROS, MCF3	Yes	No	No	No	No
ROS1 (G2101A)	ROS, MCF3	Yes	No	No	No	No
ROS1 (G2101C)	ROS, MCF3	Yes	No	No	No	No
ROS1 (L2086F)	ROS, MCF3	Yes	No	No	No	No
ROS1-GOPC	ROS, MCF3	Yes	No	No	No	No
ROS1-TPM3	ROS, MCF3	Yes	No	No	No	No
RPS6KA1	RSK1, HU-1, MAPKAPK1, p90Rsk	Yes	Yes	No	Yes	No
RPS6KA2	RSK3, HU-2	Yes	Yes	No	Yes	No
RPS6KA3	RSK2, HU-3, MRX19, CLS	Yes	Yes	No	Yes	No
RPS6KA3 (I416V)	RSK2, HU-3, MRX19, CLS	Yes	No	No	Yes	No
RPS6KA3 (L608F)	RSK2, HU-3, MRX19, CLS	Yes	No	No	Yes	No
RPS6KA4	MSK2, RSK-B	Yes	Yes	No	Yes	No
RPS6KA5	MSK1, RLPK	Yes	Yes	No	No	No
RPS6KA6	RSK4	Yes	Yes	No	Yes	No
RPS6KB1	S6K, STK14A, P70S6K	Yes	Yes	Yes	No	No
RPS6KB2	KLS, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, p70S6Kb, S6K-beta, S6Kbeta	Yes	Yes	No	No	No
SBK1	SH3-binding kinase 1	Yes	No	No	No	No
SBK3	SGK110	No	No	No	Yes	No
SGK1	SGK	Yes	Yes	No	Yes	No
SGK2	H-SGK2, dJ138B7.2	Yes	Yes	No	Yes	No
SGK3	CISK, SGK2, SGKL	Yes	Yes	No	No	No
SIK1	SIK, MSK, SNF1LK	Yes	Yes	No	Yes	No
SIK2	QIK, SNF1LK2	Yes	Yes	No	Yes	No
SIK3	L19, QSK	Yes	Yes	No	Yes	No
SLK	KIAA0204, STK2	Yes	Yes	No	Yes	No
SNRK	SNF1-related kinase	Yes	No	No	Yes	No
SPHK1	Sphingosine kinase 1	Yes	No	No	No	No
SPHK2	Sphingosine kinase 2	Yes	No	No	No	No
SRC	ASV, SRC1, c-SRC, p60-Src	Yes	Yes	Yes	Yes	No
SRC (T341M)	ASV, SRC1, c-SRC, p60-Src	Yes	No	No	No	No
SRC (Y530F)	ASV, SRC1, c-SRC, p60-Src	Yes	No	No	No	No
SRMS	C20orf148, SRM, dJ697K14.1	Yes	Yes	No	Yes	No
SRPK1	SFRSK1	Yes	Yes	No	No	No
SRPK2	SFRSK2	Yes	Yes	No	No	No
SRPK3	MSSK1, MGC102944, STK23	Yes	Yes	No	No	No
STK10	LOK, PRO2729	Yes	No	No	Yes	No
STK11	LKB1, PJS	Yes	No	No	Yes	No
STK11-CAB39-STRADA	Q15831	No	Yes	No	No	No
STK16	TSF1, PKL12, MPSK	Yes	Yes	No	Yes	No
STK17A	DRAK1	Yes	Yes	No	No	No
STK17B	O94768	No	Yes	No	Yes	No
STK24	MST3	Yes	Yes	No	Yes	No
STK25	YSK1, SOK1	Yes	Yes	No	No	No
STK26	MASK	Yes	Yes	No	Yes	No
STK3	MST2, KRS1	Yes	Yes	No	Yes	No
STK32A	YANK1	No	No	No	Yes	No
STK32B	YANK2	Yes	No	No	Yes	No
STK32C	YANK3	Yes	No	No	No	No
STK33	STK33	Yes	Yes	No	Yes	No
STK35	CLIK1, STK35L1	No	No	No	Yes	No
STK36	FU	No	No	No	Yes	No
STK38	NDR1	Yes	Yes	No	Yes	No
STK38L	NDR2, KIAA0965	Yes	Yes	No	Yes	No
STK39	STLK3, DCHT, SPAK	Yes	Yes	No	No	No
STK4	MST1, KRS2, YSK3	Yes	Yes	No	Yes	No
SYK	SYK	Yes	Yes	No	No	No
SYK (aa356-635)	P43405	No	Yes	No	No	No
TAOK1	TAO1, KIAA1361, MAP3K16, MARKK,	Yes	No	No	No	No
TAOK2	KIAA0881, MAP3K17, PSK, PSK1, TAO1, TAO2	Yes	Yes	No	No	No
TAOK3	DPK, JIK, MAP3K18, TAO kinase 3	Yes	Yes	No	No	No
TBK1	CDC37, HSPCA, HSPCB, IKBKG, NAK, T2K, TANK, TRAF2	Yes	Yes	No	Yes	No
TEC	PSCTK4	Yes	Yes	No	Yes	No
TEK	VMCM, TIE-2, VMCM1, CD202B	Yes	Yes	Yes	Yes	No
TEK (A1124V)	VMCM, TIE-2, VMCM1, CD202B	Yes	No	No	Yes	No
TEK (P883A)	VMCM, TIE-2, VMCM1, CD202B	Yes	No	No	Yes	No
TEK (R849W)	VMCM, TIE-2, VMCM1, CD202B	Yes	Yes	No	Yes	No
TEK (Y1108F)	VMCM, TIE-2, VMCM1, CD202B	Yes	Yes	No	Yes	No
TEK (Y897C)	VMCM, TIE-2, VMCM1, CD202B	Yes	No	No	Yes	No
TEK (Y897S)	VMCM, TIE-2, VMCM1, CD202B	Yes	Yes	No	Yes	No
TESK1	TESK1	Yes	No	No	Yes	No
TESK2	TESK2	Yes	No	No	No	No
TGFBR1	ALK5, ACVRLK4	Yes	Yes	No	No	No
TGFBR2	HNPCC6, MFS2, RIIC, TGFbeta-RII, TBR-II, TRBII	Yes	Yes	No	Yes	No
TIE1	JTK14, TIE	No	No	No	Yes	No
TIE2 (R915C)	TIE-2, hTIE2, TEK, p140 TEK	Yes	No	No	No	No
TIE2 (Y897H)	TIE-2, hTIE2, TEK, p140 TEK	Yes	No	No	No	No
TIE2 (Y897H/R915C)	TIE-2, hTIE2, TEK, p140 TEK	Yes	No	No	No	No
TLK1	PKU-beta, KIAA0137	Yes	Yes	No	Yes	No
TLK2	MGC44450, PKU-ALPHA	Yes	Yes	No	Yes	No
TNIK	TRAF2 and NCK interacting kinase, KIAA0551, MAP4K7	Yes	No	No	No	No
TNK1	TNK1	Yes	Yes	No	Yes	No
TNK2	ACK, p21cdc42Hs, Activated CDC42 kinase 1	Yes	Yes	No	Yes	No
TNNI3K	CARK, CCDD	No	No	No	Yes	No
TRPM7	CHAK1	Yes	No	No	No	No
TSSK1B	TSSK1, FKSG81, SPOGA4, STK22D	Yes	Yes	No	Yes	No
TSSK2	DGS-G, SPOGA2, FLJ38613, TSK2	Yes	Yes	No	No	No
TSSK3	STK22C, STK22D, SPOGA3	Yes	No	No	No	No
TSSK6	FLJ24002, SSTK	Yes	No	No	No	No
TTBK1	KIAA1855, BDTK	Yes	Yes	No	No	No
TTBK1 (aa1-480)	Q5TCY1	No	Yes	No	No	No
TTBK2	KIAA0847	Yes	Yes	No	No	No
TTK	ESK, MPS1L1, MPS1, PYT	Yes	Yes	No	Yes	No
TXK	BTKL, PSCTK5, PTK4, RLK	Yes	Yes	No	Yes	No
TYK2	JTK1	Yes	Yes	No	Yes	No
TYK2 (JH1)	JTK1	No	No	No	Yes	No
TYK2 (JH2)	JTK1	No	No	No	Yes	No
TYRO3	BYK, Brt, Dtk, Sky, Tif	Yes	Yes	No	Yes	No
ULK1	UNC51, Unc51.1	Yes	Yes	No	Yes	No
ULK2	ATG1B, KIAA0623, Unc51.2	Yes	Yes	No	Yes	No
ULK3	FLJ90566, DKFZP434C131	Yes	Yes	No	Yes	No
VRK1	VRK1	Yes	Yes	No	No	No
VRK2	VRK2	Yes	Yes	No	No	No
WEE1	WEE1hu	Yes	Yes	No	Yes	No
WEE2	FLJ16107, WEE1B	No	No	No	Yes	No
WNK1	KDP, KIAA0344, PHA2C, PRKWNK1	Yes	Yes	No	No	No
WNK2	KIAA1760, NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43	Yes	Yes	No	No	No
WNK3	KIAA1566, PRKWNK3	Yes	Yes	No	No	No
YES1	C-YES, HsT441, P61-YES, YES1, YES	Yes	Yes	No	Yes	No
YES1 (T348I)	C-YES, HsT441, P61-YES, YES1, YES	Yes	No	No	No	No
ZAP70	SRK, STD, TZK	Yes	Yes	No	No	No
ZAP70 (Y319F)	SRK, STD, TZK	Yes	No	No	No	No

Legend of HGNC References
Fusion: ALK-TFG; fusion protein including TFG and ALK
Complex: CDK4-CCND1; a complex of CDK4 and Cyclin D1 via coexpression
Mutant or deletion: FGFR3 (G687C); FGFR3 point mutant substitution Glycin 687 to Cysteine
Fragment: FAK aa411-686; FAK comprising amino acids 411 to 686. Indicated only when two different constructs are available.
CD: catalytic domain fragment
FL: full length
Isoforms: PRKCB (2); PRKCB isoform 2

Complete List of Reaction Biology’s Kinase Targets

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